Creon (Pancrelipase) Dosage and Side Effects
CREON is used to treat pancreatitis (inflammation of the pancreas), pancreatic cancer, blockage of the pancreatic ducts, and cystic fibrosis.
Proper Use of this medication
CREON comes as a delayed-release capsule to take by mouth with a meal or snack.
Follow the instructions on your prescription label carefully when taking this medicine. Don’t take more or less CREON than is recommended by your doctor.
Don’t hold the contents of a CREON capsule in your mouth, as this may cause irritation.
Also, don’t inhale the powder of a CREON capsule or allow it to touch your skin. It can irritate your nose, lungs, and skin.
You can open the capsule and sprinkle its contents into pudding or applesauce, if needed. Swallow the mixture immediately without chewing it. Don’t save any of the mixture for later.
The contents of a CREON capsule must be swallowed right after the capsule is opened. Discard any unused medicine.
Don’t crush or chew CREON capsules.
Pancrelipase is sold under brand names other than CREON. Don’t switch to a different brand of the medicine without first talking with your healthcare provider.
Taking CREON regularly results in the greatest benefit. Be sure to get your prescription refilled before you run out of medicine.
Common Side Effects of CREON
Tell your doctor if any of the following side effects become severe or don’t go away:
•Cough or sore throat
•Nausea or upset stomach
•Feeling full after eating a small amount of food
•Sore mouth or tongue
•Irritation around the rectum
Serious Side Effects of CREON
Tell your doctor right away if you experience any of the following serious side effects:
•Signs of an allergic reaction (may include hives, rash, itching, chest tightness, or swelling of the face, lips, tongue, or throat)
•Severe nausea or vomiting
•Severe or unusual stomach pain
•Difficulty having bowel movements
•Pain or swelling in your joints, especially in your big toe
Warnings and Precautions
Before taking CREON, tell your doctor if you have, or have ever had:
•Gout or high levels of uric acid in the blood
•Surgery on your intestines
•A blockage, thickening, or scarring of your intestines
•Trouble swallowing capsules
•Allergies to medications
CREON is made from the pancreas of pigs. Tell your doctor if you’re allergic to pork products.
It may be possible to get a viral infection from products that come from pigs, but this has never been reported with CREON.
CREON may raise your risk of developing a rare bowel disorder called fibrosing colonopathy. You can reduce this risk by following the dosing instructions that your doctor provides.
Don’t take CREON if you have a sudden onset of pancreatitis, or experience worsening of a problem with your pancreas.
Your doctor may recommend that you follow a specific diet plan while taking this medicine. Follow your doctor’s instructions carefully.
Pregnancy and CREON
It’s not known whether CREON can harm an unborn baby.
Tell your doctor if you’re pregnant, or plan to become pregnant while taking this medicine.
It’s also not known whether CREON passes into breast milk or could hurt a breastfeeding baby.
Talk to your doctor before using this drug while breastfeeding.
Interactions with this medication
Tell your doctor about all prescription, nonprescription, illegal, recreational, herbal, nutritional, or dietary drugs you’re taking before starting on CREON.